製品の概要

  • 製品名

    (plusminus)-Chlorpheniramine maleate, H1 antagonist
  • 製品の詳細

    Potent H1 antagonist and SNRI
  • 生理活性の詳細

    Potent H1 antagonist (Ki = 2 nM) and serotonin-norepinephrine reuptake inhibitor (SNRI). Shows antiallergic, antidepressant and antianxiolytic activity.
  • 精製度

    > 99%
  • CAS 番号

    113-92-8
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Miyata S  et al. Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice. Psychopharmacology (Berl) 213:441-52 (2011). Read more (PubMed: 19823805) »
  • Rojas-Zamorano JA  et al. The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats. Pharmacol Biochem Behav 91:291-4 (2009). Read more (PubMed: 18700151) »
  • Aslanian R  et al. Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine. Bioorg Med Chem Lett 13:1959-61 (2003). Read more (PubMed: 12781173) »

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