製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Plexin A1
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WB, ELISA, IP, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Plexin A1 aa 182-200.
    Sequence:

    RLMANEEDADMFGFVYQDE

  • ポジティブ・コントロール
    • Cos 7 cells transfected with mouse Plexin A1 or neonatal rat brain.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab23391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 195 kDa.
ELISA 1/2000.
IP 1/50 - 1/200.
ICC/IF 1/200. (see Abreview).

ターゲット情報

  • 関連性
    Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Tissue specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.
  • 細胞内局在
    Cell Membrane
  • 参照データベース
  • 別名
    • NOV antibody
    • NOV/plexin A1 protein antibody
    • NOVP antibody
    • Plexin-A1 antibody
    • Plexin1 antibody
    • PlexinA1 antibody
    • PLXA1_HUMAN antibody
    • PLXN1 antibody
    • Plxna1 antibody
    • PLXNA1 protein antibody
    • Semaphorin receptor NOV antibody
    see all

画像

  • Western blots showing Cos-7 cells transfected with mouse myc-tagged Plexin-A1 (lanes 1 & 3), neonatal rat brain (lane 2), or Plexin-A1 immunoprecipitated from myc-tagged Plexin-A1 transfected cells using anti-Myc (lane 4) or anti-Plexin-A1 (ab23391; lane 5). These blots were probed with either the affinity purified anti-Plexin-A1 (ab23391; lanes 1 & 2) or with mouse monoclonal anti-Myc (lanes 3-5).

参考文献

This product has been referenced in:
  • Delloye-Bourgeois C  et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci 18:36-45 (2015). Read more (PubMed: 25485759) »
  • Hernandez-Enriquez B  et al. Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing. Genes Dev 29:2617-32 (2015). Read more (PubMed: 26680304) »
See all 8 Publications for this product

レビューと Q&A

1-2 of 2 Q&A

Question
Answer

Thank you for contacting us. For ab23391, the blocking peptide is ab42757. For ab25999, the blocking peptide is ab42770. If you have any other questions, please do not hesitate to contact us.

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Question
Answer

Thank you for your enquiry. This antibody was tested for Plexin-A1 reactivity using transfected cells. It was not tested against other Plexin family members. However, the immunogen was chosen based on low homology to other family members. The only significant homology found in BLASTs of the immunogen show 57% homology to Plexin-A3. I hope this information helps. Please do not hesitate to contact us if you need anything further.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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