製品の概要
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製品名Anti-Plexin A1 antibody
Plexin A1 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to Plexin A1
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由来種Rabbit
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アプリケーション適用あり: WB, ELISA, IP, ICC/IFmore details
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種交差性交差種: Mouse, Rat, Human
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免疫原
Synthetic peptide corresponding to Human Plexin A1 aa 182-200.
Sequence:RLMANEEDADMFGFVYQDE
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ポジティブ･コントロール
- Cos 7 cells transfected with mouse Plexin A1 or neonatal rat brain.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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バッファーPreservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 1mg/ml BSA -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab23391 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/1000. Predicted molecular weight: 195 kDa. | |
| ELISA | 1/2000. | |
| IP | 1/50 - 1/200. | |
| ICC/IF | 1/200. (see Abreview). |
ターゲット情報
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関連性Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Tissue specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.
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細胞内局在Cell Membrane
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参照データベース
- Entrez Gene: 5361 Human
- Entrez Gene: 18844 Mouse
- NCBI: NP_115618 Human
- Omim: 601055 Human
- SwissProt: Q9UIW2 Human
- SwissProt: P70206 Mouse
- Unigene: 432329 Human
- Unigene: 549421 Human
see all -
別名
- NOV antibody
- NOV/plexin A1 protein antibody
- NOVP antibody
see all
画像
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Western blot - Anti-Plexin A1 antibody (ab23391)Western blots showing Cos-7 cells transfected with mouse myc-tagged Plexin-A1 (lanes 1 & 3), neonatal rat brain (lane 2), or Plexin-A1 immunoprecipitated from myc-tagged Plexin-A1 transfected cells using anti-Myc (lane 4) or anti-Plexin-A1 (ab23391; lane 5). These blots were probed with either the affinity purified anti-Plexin-A1 (ab23391; lanes 1 & 2) or with mouse monoclonal anti-Myc (lanes 3-5).
プロトコール
参考文献
This product has been referenced in:
- Delloye-Bourgeois C et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci 18:36-45 (2015). Read more (PubMed: 25485759) »
- Hernandez-Enriquez B et al. Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing. Genes Dev 29:2617-32 (2015). Read more (PubMed: 26680304) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"