PK11195, benzodiazepine receptor antagonist (ab120378)
Key features and details
- Peripheral benzodiazepine receptor antagonist
- CAS Number: 85532-75-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
PK11195, benzodiazepine receptor antagonist -
製品の詳細
Peripheral benzodiazepine receptor antagonist -
生理活性の詳細
Antagonist at the mitochondrial (peripheral) benzodiazepine receptor (translocator protein, TSPO). Acts as a chemosensitizer of tumor cells to a wide range of chemotherapeutic agents.
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精製度
> 99% -
CAS 番号
85532-75-8 -
構造式
製品の特性
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体系名
N-sec-Butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide -
分子量
352.86 -
分子式
C21H21ClN2O -
PubChem 登録番号
1345 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(CC)N(C)C(=O)c2cc1ccccc1c(n2)c3ccccc3Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120378 は 2 報の論文で使用されています。
- Luo A et al. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. J Transl Med 21:71 (2023). PubMed: 36732752
- Walker MD et al. [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat. J Cereb Blood Flow Metab 35:1331-8 (2015). PubMed: 25833342