製品名Anti-PIP5KI gamma antibody [MAO-R1]
PIP5KI gamma 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [MAO-R1] to PIP5KI gamma
アプリケーション適用あり: WB, IPmore details
適用なし: Flow Cyt,ICC or IHC-P
種交差性交差種: Mouse, Rat, Human
Recombinant full length protein within Mouse PIP5KI gamma. The exact sequence is proprietary.
- K562, Human fetal kidney, C6, Neuro-2a, and 293T cell lysates
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant
精製度Tissue culture supernatant
Our Abpromise guarantee covers the use of ab109192 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Detects a band of approximately 80-90 kDa (predicted molecular weight: 73 kDa).|
|IP||1/10 - 1/100.|
機能Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate.
関連疾患Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
配列類似性Contains 1 PIPK domain.
細胞内局在Cell membrane. Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
- Information by UniProt
- Diphosphoinositide kinase antibody
- LCCS3 antibody
- Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody
This product has been referenced in:
- Tojima T et al. Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis. J Neurosci 34:7165-78 (2014). Read more (PubMed: 24849351) »
- Chen C et al. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 122:2916-27 (2012). Read more (PubMed: 22772469) »