製品の概要

  • 製品名

    PIK 75 hydrochloride, p110alpha PI3K inhibitor
  • 製品の詳細

    Selective p110α PI3K inhibitor
  • 生理活性の詳細

    Selective inhibitor of p110α (IC50 values are 5.8, 76 nM and 1.3 μM at p110α, p110γ and p110β, respectively). Inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and activation of mTORC1. Cell-permeable.
  • 精製度

    > 98%
  • CAS 番号

    372196-77-5
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Aoyagi K  et al. Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic ß-cells. PLoS One 7:e47381 (2012). Read more (PubMed: 23077605) »
  • Moir LM  et al. Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function. J Pharmacol Exp Ther 337:557-66 (2011). Read more (PubMed: 21349933) »
  • Knight ZA  et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 125:733-47 (2006). Read more (PubMed: 16647110) »

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