製品の概要

  • 製品名
    PFK15
  • 製品の詳細
    Potent, selective 6-phosphofructo-2-kinase (PFK) inhibitor
  • 生理活性の詳細
    Potent and selective 6-phosphofructo-2-kinase (PFK) inhibitor (IC50 = 207 nM). Rapidly induces apoptosis in transformed cells. Suppresses glucose uptake and growth in cancer cells. Show antitumor effects in vivo.
  • 精製度
    > 99%

製品の特性

  • 体系名
    (E)-1-Pyridin-4-yl-3-quinolin-2-ylprop-2-en-1-one
  • 分子量
    260.29
  • 構造式
    Chemical Structure
  • 分子式
    C17H12N2O
  • CAS 番号
    4382-63-2
  • PubChem 登録番号
    25142799
  • 保存方法
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in ethanol to 5 mM and in DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Clem BF  et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther 12:1461-70 (2013). Read more (PubMed: 23674815) »
  • Mustroph A  et al. Characterization of the phosphofructokinase gene family in rice and its expression under oxygen deficiency stress. Front Plant Sci 4:125 (2013). Read more (PubMed: 23717315) »
  • Jia SS & Liu YH [Effects of estrogen on the expression of phosphofructokinase muscle-specific isoform in genioglossus of chronic intermittent hypoxia rats]. Zhonghua Kou Qiang Yi Xue Za Zhi 45:627-30 (2010). Read more (PubMed: 21176602) »

See 1 Publication for this product

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