PE Anti-TNF Receptor I 抗体 [H398] (ab270654)

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Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)
  • Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)

Key features and details

  • PE Mouse monoclonal [H398] to TNF Receptor I
  • Suitable for: Flow Cyt
  • Reacts with: Human
  • Conjugation: PE. Ex: 488nm, Em: 575nm
  • Isotype: IgG2a

製品の概要

  • 製品名

    PE Anti-TNF Receptor I antibody [H398]
    TNF Receptor I 一次抗体 製品一覧

  • 製品の詳細

    PE Mouse monoclonal [H398] to TNF Receptor I

  • 由来種

    Mouse

  • 標識

    PE. Ex: 488nm, Em: 575nm

  • Tested Applications & Species

    Application Species
    Flow Cyt
    Human
    See all applications and species data

  • 免疫原

    Recombinant full length protein corresponding to Human TNF Receptor I.
    Database link: P19438

  • ポジティブ･コントロール

    • Flow: Human peripheral blood and human monocytes.

製品の特性

関連製品

    アプリケーション

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab270654 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    アプリケーション Species
    Flow Cyt
    Human
    アプリケーション Abreviews 特記事項
    Flow Cyt
    Use 10µl for 106 cells.
    特記事項
    Flow Cyt
    Use 10µl for 106 cells.

    ターゲット情報

    • 機能

      Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

    • 関連疾患

      Familial hibernian fever
      Multiple sclerosis 5

    • 配列類似性

      Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.

    • ドメイン

      The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
      Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.

    • 翻訳後修飾

      The soluble form is produced from the membrane form by proteolytic processing.

    • 細胞内局在

      Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
    • Information by UniProt

    • 参照データベース

      • 別名

        • CD120a antibody
        • FPF antibody
        • MGC19588 antibody
        • p55 antibody
        • p55-R antibody
        • p60 antibody
        • TBP1 antibody
        • TBPI antibody
        • TNF R antibody
        • TNF R55 antibody
        • TNF-R1 antibody
        • TNF-RI antibody
        • TNFAR antibody
        • TNFR-I antibody
        • TNFR1 antibody
        • TNFR55 antibody
        • TNFR60 antibody
        • TNFRI antibody
        • TNFRSF1a antibody
        • TNR1A_HUMAN antibody
        • Tumor necrosis factor receptor 1 antibody
        • Tumor necrosis factor receptor superfamily, member 1A antibody
        • Tumor necrosis factor receptor type 1 antibody
        • Tumor necrosis factor receptor type I antibody
        • Tumor necrosis factor-binding protein 1 antibody
        see all

      画像

      • Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)
        Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)

        Flow cytometry analysis of human monocytes (red) and lymphocytes (black) cells labeling CD120a using ab270654. Concentration of 10 μl reagent/100μl peripheral whole blood.

      • Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)
        Flow Cytometry - PE Anti-TNF Receptor I antibody [H398] (ab270654)

        Flow cytometric analysis of human peripheral whole blood cells labeling TNF Receptor I using ab270654. The concentration of 10 μl reagent/ 100µl of peripheral whole blood.

      プロトコール

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      参考文献 (0)

      ab270654 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab270654 は論文での使用が確認できていません。

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