PE Anti-SLAMF7/CS1 抗体 [162] (ab95827)
Key features and details
- PE Mouse monoclonal [162] to SLAMF7/CS1
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2b
製品の概要
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製品名
PE Anti-SLAMF7/CS1 antibody [162]
SLAMF7/CS1 一次抗体 製品一覧 -
製品の詳細
PE Mouse monoclonal [162] to SLAMF7/CS1 -
由来種
Mouse -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human SLAMF7/CS1.
Database link: Q9NQ25 -
ポジティブ・コントロール
- Normal Human peripheral blood cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: BSA, PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
162 -
アイソタイプ
IgG2b -
軽鎖の種類
kappa -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95827の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 5µl for 106 cells.
ab91532 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
|
特記事項 |
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Flow Cyt
Use 5µl for 106 cells. ab91532 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
|
ターゲット情報
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関連性
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms. -
細胞内局在
Membrane; Single-pass type I membrane protein. -
参照データベース
- Entrez Gene: 57823 Human
- Omim: 606625 Human
- SwissProt: Q9NQ25 Human
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別名
- 19A antibody
- 19A24 protein antibody
- CD 319 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (3)
ab95827 は 3 報の論文で使用されています。
- Lum LG et al. Anti-CS1 × Anti-CD3 Bispecific Antibody (BiAb)-Armed Anti-CD3 Activated T Cells (CS1-BATs) Kill CS1+ Myeloma Cells and Release Type-1 Cytokines. Front Oncol 10:544 (2020). PubMed: 32432032
- Tassi I & Colonna M The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol 175:7996-8002 (2005). PubMed: 16339536
- Bouchon A et al. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J Immunol 167:5517-21 (2001). PubMed: 11698418