PE Anti-OX40L/TNFSF4 抗体 [RM134L] (ab95656)
Key features and details
- PE Rat monoclonal [RM134L] to OX40L/TNFSF4
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2b
製品の概要
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製品名
PE Anti-OX40L/TNFSF4 antibody [RM134L]
OX40L/TNFSF4 一次抗体 製品一覧 -
製品の詳細
PE Rat monoclonal [RM134L] to OX40L/TNFSF4 -
由来種
Rat -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Full length protein corresponding to Mouse OX40L/TNFSF4. Native protein
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ポジティブ・コントロール
- Anti-Mouse IgM and Anti-Mouse CD40 stimulated Mouse BALB/c splenocytes
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特記事項
The RM134L monoclonal antibody inhibits the costimulatory activity of Mouse CD252 transfected cells for anti-CD3-stimulated T cell proliferation.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS -
Concentration information loading...
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精製度
Protein G purified -
一次抗体 備考
The RM134L monoclonal antibody inhibits the costimulatory activity of Mouse CD252 transfected cells for anti-CD3-stimulated T cell proliferation. -
ポリ/モノ
モノクローナル -
クローン名
RM134L -
アイソタイプ
IgG2b -
軽鎖の種類
kappa -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab95656の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use 0.25-0.5µg for 105-8 cells.
Staining the cell sample in a final volume of 100 µl is recommended. |
特記事項 |
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Flow Cyt
Use 0.25-0.5µg for 105-8 cells. Staining the cell sample in a final volume of 100 µl is recommended. |
ターゲット情報
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機能
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. -
関連疾患
Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance. -
配列類似性
Belongs to the tumor necrosis factor family. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 22164 Mouse
- SwissProt: P43488 Mouse
- Unigene: 4994 Mouse
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別名
- CD 134L antibody
- CD 252 antibody
- CD134 ligand antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab95656 は 3 報の論文で使用されています。
- Tsukada N et al. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood 95:2434-9 (2000). PubMed: 10733518
- Akiba H et al. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 191:375-80 (2000). PubMed: 10637281
- Akiba H et al. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 162:7058-66 (1999). PubMed: 10358148