Anti-PDE6 alpha 抗体 (ab5660)

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Western blot - Anti-PDE6 alpha antibody (ab5660)

    Key features and details

    • Rabbit polyclonal to PDE6 alpha
    • Suitable for: WB
    • Reacts with: Sheep, Cow
    • Isotype: IgG

    製品の概要

    • 製品名

      Anti-PDE6 alpha antibody
      PDE6 alpha 一次抗体 製品一覧

    • 製品の詳細

      Rabbit polyclonal to PDE6 alpha

    • 由来種

      Rabbit

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Sheep, Cow
      交差が予測される動物種: Mouse, Chicken, Human

    • 免疫原

      Synthetic peptide corresponding to Human PDE6C aa 16-29.
      Sequence:

      MPQFAKEYFDRKLR


      (Peptide available as ab5863)
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • ポジティブ･コントロール

      • WB: sheep retinal extract.

    • 特記事項

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab5660 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    WB 1/500. Detects a band of approximately 90 kDa.

    ターゲット情報

    • 機能

      This protein participates in processes of transmission and amplification of the visual signal.

    • 関連疾患

      Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

    • 配列類似性

      Belongs to the cyclic nucleotide phosphodiesterase family.
      Contains 2 GAF domains.

    • 細胞内局在

      Cell membrane.
    • Information by UniProt

    • 参照データベース

      see all

    • 別名

      • 5''-cyclic phosphodiesterase subunit alpha antibody
      • CGPR A antibody
      • GMP PDE alpha antibody
      • GMP-PDE alpha antibody
      • PDE 6 alpha antibody
      • PDE 6A antibody
      • PDE V B1 antibody
      • PDE V-B1 antibody
      • PDE6A antibody
      • PDE6A_HUMAN antibody
      • PDEA antibody
      • Phosphodiesterase 6 alpha antibody
      • Phosphodiesterase 6A alpha subunit antibody
      • Phosphodiesterase 6A antibody
      • Phosphodiesterase 6A cGMP specific rod alpha antibody
      • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody
      • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody
      • Rod cGMP-specific 3'' antibody
      see all

    画像

    • Western blot - Anti-PDE6 alpha antibody (ab5660)
      Western blot - Anti-PDE6 alpha antibody (ab5660)

      Western blot of PDE6C on sheep retinal extracts using ab5660.

    参考文献 (1)

    ab5660 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab5660 は 1 報の論文で使用されています。

    • Iribarne M  et al. Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish. Sci Rep 7:45962 (2017). WB ; Zebrafish . PubMed: 28378769

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