Anti-PDE1C/PDE1 抗体 (ab14602)
Key features and details
- Rabbit polyclonal to PDE1C/PDE1
- Suitable for: IP, IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
-
製品名
Anti-PDE1C/PDE1 antibody
PDE1C/PDE1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PDE1C/PDE1 -
由来種
Rabbit -
特異性
The antibody does not cross react with PDE1A, PDE1B or other PDEs. -
アプリケーション
適用あり: IP, IHC-P, WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab14602の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IP |
Use at an assay dependent concentration.
|
|
IHC-P |
Use at an assay dependent concentration. PubMed: 19924104
|
|
WB |
1/250 - 1/500. Predicted molecular weight: 70 kDa. This antibody labels multiple bands in the 70-87 kDa range all believed to be various PDE1C variants.
|
特記事項 |
---|
IP
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. PubMed: 19924104 |
WB
1/250 - 1/500. Predicted molecular weight: 70 kDa. This antibody labels multiple bands in the 70-87 kDa range all believed to be various PDE1C variants. |
ターゲット情報
-
機能
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. -
組織特異性
Expressed in several tissues, including brain and heart. -
配列類似性
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. - Information by UniProt
-
参照データベース
- Entrez Gene: 5137 Human
- Entrez Gene: 18575 Mouse
- Entrez Gene: 81742 Rat
- Omim: 602987 Human
- SwissProt: Q14123 Human
- SwissProt: Q64338 Mouse
- SwissProt: Q63421 Rat
- Unigene: 728862 Human
see all -
別名
- 5''-cyclic nucleotide phosphodiesterase 1C antibody
- Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody
- Calcium/calmodulin-dependent 3'' antibody
see all
画像
-
All lanes : Anti-PDE1C/PDE1 antibody (ab14602) at 1/500 dilution
Lane 1 : Brain lysate
Lane 2 : Heart lysate
Lane 3 : Lung lysate
Lane 4 : Testis lysate
Lane 5 : Kidney lysate
Predicted band size: 70 kDaWestern Blot analysis of PDE1C/PDE1 with ab14602 (1/500). Rat tissues: 1- Brain; 2 -Heart; 3 - Lung; 4 - Testis; 5 - Kidney.
データシートおよび資料
-
Datasheet download
参考文献 (7)
ab14602 は 7 報の論文で使用されています。
- Muller GK et al. PDE1 Inhibition Modulates Cav1.2 Channel to Stimulate Cardiomyocyte Contraction. Circ Res 129:872-886 (2021). PubMed: 34521216
- Li EA et al. Phosphodiesterase expression in the normal and failing heart. Arch Biochem Biophys 662:160-168 (2019). PubMed: 30550727
- Pinto CS et al. Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol 27:1124-34 (2016). PubMed: 26289612
- He J et al. Postnatal experience modulates functional properties of mouse olfactory sensory neurons. Eur J Neurosci 36:2452-60 (2012). PubMed: 22703547
- Giachini FR et al. Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension 57:655-63 (2011). WB ; Rat . PubMed: 21282562
- Lee AC et al. Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference. J Neurosci 31:2974-82 (2011). WB ; Mouse . PubMed: 21414919
- Wang X et al. Cyclic nucleotide signaling in polycystic kidney disease. Kidney Int 77:129-40 (2010). IHC-P ; Mouse, Rat . PubMed: 19924104