Anti-PD-L2 抗体 (ab200377)
Key features and details
- Rabbit polyclonal to PD-L2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PD-L2 antibody
PD-L2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PD-L2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human PD-L2 (internal sequence). The exact sequence is proprietary.
Database link: Q9BQ51 -
ポジティブ・コントロール
- Human thyroid cancer tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab200377の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/25 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
ターゲット情報
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機能
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. -
組織特異性
Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. -
配列類似性
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
細胞内局在
Secreted; Cell membrane and Endomembrane system. - Information by UniProt
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参照データベース
- Entrez Gene: 80380 Human
- Omim: 605723 Human
- SwissProt: Q9BQ51 Human
- Unigene: 532279 Human
- Unigene: 617872 Human
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別名
- B7 dendritic cell molecule antibody
- B7-DC antibody
- B7DC antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab200377 は 9 報の論文で使用されています。
- Pasternack H et al. Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas. Sci Rep 11:9532 (2021). PubMed: 33953302
- da Silva JL et al. Prognostic Influence of Residual Tumor-Infiltrating Lymphocyte Subtype After Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer. Front Oncol 11:636716 (2021). PubMed: 34858800
- da Silva JL et al. The prevalence and prognostic impact of tumor-infiltrating lymphocytes in uterine carcinosarcoma. BMC Cancer 21:1306 (2021). PubMed: 34876047
- Huang KC et al. Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy. Sci Rep 10:22330 (2020). PubMed: 33339860
- Tcvetkov N et al. Immune checkpoints bone marrow expression as the predictor of clinical outcome in myelodysplastic syndrome. Leuk Res Rep 14:100215 (2020). PubMed: 32695574
- Sungu N et al. Expression of Immunomodulatory Molecules PD-1, PD-L1, and PD-L2, and their Relationship With Clinicopathologic Characteristics in Endometrial Cancer. Int J Gynecol Pathol 38:404-413 (2019). PubMed: 30134343
- Genova C et al. Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab. J Clin Med 8:N/A (2019). PubMed: 31581482
- Zhang X et al. Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma. BMC Cancer 19:360 (2019). PubMed: 30992011
- Guo PD et al. Clinicopathological analysis of PD-L2 expression in colorectal cancer. Onco Targets Ther 11:7635-7642 (2018). PubMed: 30464512