製品の概要

  • 製品名

    PD 168077 maleate, D4 agonist
  • 製品の詳細

    Potent, selective D4 agonist
  • 生理活性の詳細

    Potent, selective D4 dopamine receptor agonist. Displays >400-fold selectivity over D2 and >300-fold selectivity over D3 subtypes (Ki values are 11.9, 2540, and 1050 nM for D4, D3, and D2 receptors, respectively). Reverses object recognition deficits.
  • 精製度

    > 98%
  • 特記事項

    This product appears to be unstable in ethanol solution

  • CAS 番号

    190383-31-4
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Sood P  et al. PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia. J Psychopharmacol 25:792-800 (2011). Read more (PubMed: 21088042) »
  • Basso AM  et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30:1257-68 (2005). Read more (PubMed: 15688083) »
  • Nayak S & Cassaday HJ The novel dopamine D4 receptor agonist (PD 168,077 maleate): doses with different effects on locomotor activity are without effect in classical conditioning. Prog Neuropsychopharmacol Biol Psychiatry 27:441-9 (2003). Read more (PubMed: 12691779) »

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