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Wnt signaling pathway poster

See how activation of the canonical and non-canonical Wnt signaling pathways lead to the regulation of numerous downstream targets.

Download the Wnt signaling pathway poster here 

Wnt signaling – an overview

The Wnt signaling pathway was discovered more than 35 years ago but still, researchers are making new exciting discoveries based on this pathway even today1.  Wnt signaling is relevant for many fields of research including cell proliferation and differentiation in development, stem cell renewal, and cancer progression1,2.  This is why it is important for many scientists to understand the core components of the pathway and what can go wrong to lead to disease progression1

Canonical Wnt signaling

In this poster, you can see the downstream effects on the Wnt signaling components after binding of Wnt ligands to their Frizzled receptors. This activation is known to lead to accumulation of β-catenin which can enter the nucleus, activating transcription of Wnt-dependent genes eg c-myc. Conversely, you can also see the downstream consequence of Wnt inhibitors (eg DKK, WIF, and sFRP) binding to Frizzled receptors. This leads to the proteasomal degradation of β-catenin via ubiquitination. 

Non-canonical Wnt signaling

This poster also covers non-canonical Wnt signaling – the planar cell polarity (PCP) and the Wnt/calcium pathways. Activation of the PCP pathway leads to activation of downstream MAPK signaling resulting in cell survival or gene repression. Alternatively, it may activate Rock/Rho signaling leading to cytoskeletal rearrangement. Non-canonical Wnt signaling can also go down the route of the Wnt/calcium pathway. You can see here how this pathway may also lead to cytoskeletal rearrangement and activation of Wnt/calcium-dependent genes. 


References

  • 1) Nusse R., Clevers H.  (2018) Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169, 985–999
  • 2)
    Steinhart Z, Angers S.Wnt signaling in development and tissue homeostasis. Development 145 
     Steinhart Z., Angers S. (2018) Wnt signaling in development and tissue homeostasis. Development 145.
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