Anti-P4HA3 抗体 (ab101657)
Key features and details
- Rabbit polyclonal to P4HA3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-P4HA3 antibody -
製品の詳細
Rabbit polyclonal to P4HA3 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to internal sequence amino acids 130-396 of Human P4HA3 (BC117333).
-
ポジティブ・コントロール
- Human fetal kidney & liver lysates, Human fetal liver tissue.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab101657の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 61 kDa.
|
|
IHC-P |
1/100 - 1/500.
|
特記事項 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 61 kDa. |
IHC-P
1/100 - 1/500. |
ターゲット情報
-
機能
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. -
組織特異性
Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. -
配列類似性
Belongs to the P4HA family.
Contains 1 Fe2OG dioxygenase domain.
Contains 1 TPR repeat. -
翻訳後修飾
N-glycosylation plays no role in the catalytic activity. -
細胞内局在
Endoplasmic reticulum lumen. - Information by UniProt
-
参照データベース
- Entrez Gene: 283208 Human
- Entrez Gene: 320452 Mouse
- Entrez Gene: 361612 Rat
- Omim: 608987 Human
- SwissProt: Q7Z4N8 Human
- SwissProt: Q6W3F0 Mouse
- SwissProt: Q6W3E9 Rat
- Unigene: 660541 Human
see all -
別名
- 2-oxoglutarate-4-dioxygenase subunit alpha-3 antibody
- 4-PH alpha-3 antibody
- P4ha3 antibody
see all
画像
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (7)
ab101657 は 7 報の論文で使用されています。
- Xiao Z et al. Profiling of miR-205/P4HA3 Following Angiotensin II-Induced Atrial Fibrosis: Implications for Atrial Fibrillation. Front Cardiovasc Med 8:609300 (2021). PubMed: 33981730
- Wang J et al. Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206+ M2-like macrophage polarization. Cell Death Dis 11:136 (2020). PubMed: 32075954
- Gu X et al. Age-associated genes in human mammary gland drive human breast cancer progression. Breast Cancer Res 22:64 (2020). PubMed: 32539762
- Long R et al. COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway. Aging (Albany NY) 11:8845-8859 (2019). PubMed: 31627190
- Song H et al. P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival. Technol Cancer Res Treat 17:1533033818796485 (2018). PubMed: 30198421
- Olivares O et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun 8:16031 (2017). WB, IHC . PubMed: 28685754
- Akamatsu T et al. Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences. Fibrogenesis Tissue Repair 6:15 (2013). IHC-P . PubMed: 23927729