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RabMAb

Anti-p130 (phospho T986) 抗体 [EPR2389(2)] - BSA and Azide free (ab251534)

製品の概要

  • 製品名

    Anti-p130 (phospho T986) antibody [EPR2389(2)] - BSA and Azide free
    p130 一次抗体 製品一覧
  • 製品の詳細

    Rabbit monoclonal [EPR2389(2)] to p130 (phospho T986) - BSA and Azide free
  • 由来種

    Rabbit
  • アプリケーション

    適用あり: Flow Cyt, WB, IPmore details
  • 種交差性

    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide within Human p130 aa 950-1050 (phospho T986). The exact sequence is proprietary.
    Database link: Q08999

  • 特記事項

    ab251534 is a PBS-only buffer format of ab211928. Please refer to ab211928 for recommended dilutions, protocols, and image data.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab251534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能

    Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 配列類似性

    Belongs to the retinoblastoma protein (RB) family.
  • 発生段階

    G0-restricted expression.
  • 翻訳後修飾

    During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.
  • 細胞内局在

    Nucleus.
  • Information by UniProt
  • 参照データベース

  • 別名

    • 130 kDa retinoblastoma associated protein antibody
    • 130 kDa retinoblastoma-associated protein antibody
    • IB4 antibody
    • p130 antibody
    • PPAR-alpha-interacting complex protein 128 antibody
    • PRB2 antibody
    • Rb2 antibody
    • Rbl2 antibody
    • RBL2_HUMAN antibody
    • RBR 2 antibody
    • RBR-2 antibody
    • RBR2 antibody
    • Retinoblastoma like 2 antibody
    • Retinoblastoma-like protein 2 antibody
    • Retinoblastoma-related protein 2 antibody
    • RIC128 antibody
    see all

参考文献

ab251534 has not yet been referenced specifically in any publications.

レビューと Q&A

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