Oxaliplatin, Platinum anticancer agent (ab141054)
Key features and details
- Platinum anticancer agent. Induces DNA cross-linking.
- CAS Number: 61825-94-3
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Oxaliplatin, Platinum anticancer agent -
製品の詳細
Platinum anticancer agent. Induces DNA cross-linking. -
生理活性の詳細
Diaminocyclohexane platinum anticancer agent. Induces DNA cross-linking and blocks DNA synthesis. Induces apoptosis and cell cycle arrest.
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精製度
> 99% -
CAS 番号
61825-94-3 -
構造式
製品の特性
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体系名
(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN1,kN2][ethanedioato(2-)-kO1,kO2]-platinum -
分子量
397.29 -
分子式
C8H14N2O4Pt -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab141054 は 5 報の論文で使用されています。
- Fernández Moro C et al. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver. Nat Commun 14:5024 (2023). PubMed: 37596278
- Li D et al. Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS. Aging (Albany NY) 13:4242-4257 (2021). PubMed: 33495407
- Tan Z et al. Environmental stresses induce karyotypic instability in colorectal cancer cells. Mol Biol Cell 30:42-55 (2019). PubMed: 30379607
- Yan S et al. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31671668
- Vallecillo-Hernández J et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep 8:3593 (2018). PubMed: 29483523