Anti-ORC1 抗体 [7F6/1] - ChIP Grade (ab60)
Key features and details
- Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-ORC1 antibody [7F6/1] - ChIP Grade
ORC1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade -
由来種
Mouse -
種交差性
交差種: Human -
免疫原
Recombinant full length protein (Human)
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ポジティブ・コントロール
- HeLa cells.
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特記事項
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
7F6/1 -
ミエローマ
Sp2/0-Ag14 -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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ChIP Related Products
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Compatible Secondaries
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Isotype control
ターゲット情報
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機能
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. -
配列類似性
Belongs to the ORC1 family.
Contains 1 BAH domain. -
発生段階
Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level). -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 4998 Human
- Omim: 601902 Human
- SwissProt: Q13415 Human
- Unigene: 17908 Human
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別名
- HSORC1 antibody
- MmORC1 antibody
- orc1 antibody
see all
データシートおよび資料
参考文献 (3)
ab60 は 3 報の論文で使用されています。
- Lu F et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5:1449-1460 (2016). PubMed: 27744293
- Beck DB et al. The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev 26:2580-9 (2012). WB, ChIP ; Human . PubMed: 23152447
- Salsi V et al. HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin. Mol Cell Biol 29:5775-88 (2009). ChIP ; Human, Mouse . PubMed: 19703996