製品の概要

  • 製品名

    O-1602, GPR55 agonist
  • 製品の詳細

    Potent, selective GPR55 agonist
  • 生理活性の詳細

    Analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, >30000 and >30000 nM for GPR55, CB1 and CB2 receptors, respectively). Inhibits mouse osteoclast formation in vitro, stimulates osteoclast polarization and resorption, causes activation of Rho and ERK1/2, and inhibits human neutrophil migration.
  • 精製度

    > 98%
  • 特記事項

    Sold under license from Virginia Commonwealth University.
  • CAS 番号

    317321-41-8
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Whyte LS  et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A 106:16511-6 (2009). Read more (PubMed: 19805329) »
  • McHugh D  et al. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol Pharmacol 73:441-50 (2008). Read more (PubMed: 17965195) »
  • Ryberg E  et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-101 (2007). Read more (PubMed: 17876302) »
See 1 Publication for this product

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