製品の概要

  • 製品名

    NVP-BEZ235, PI3K and mTOR inhibitor
  • 製品の詳細

    Potent PI3K and mTOR inhibitor
  • 別名

    • BEZ-235
    • BEZ235
    • Dactolisib
  • 生理活性の詳細

    Potent, ATP-competitive Phosphatidylinositol 3-kinase (PI3K) inhibitor (IC50 = 4, 5, 7 and 75 nM for PI3Kα, -γ, -δ, and -β respectively) and mTOR inhibitor. Able to directly induce G1 arrest and inhibit angiogenesis in vitro and potentiate the efficacy of other anticancer agents in vivo.

  • 精製度

    > 98%
  • CAS 番号

    915019-65-7
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Moon du G  et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells. Int J Oncol 45:1027-35 (2014). Read more (PubMed: 24969552) »
  • Roper J  et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. PLoS One 6:e25132 (2011). Read more (PubMed: 21966435) »
  • Maira SM  et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7:1851-63 (2008). Read more (PubMed: 18606717) »
  • Serra V  et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 68:8022-30 (2008). Read more (PubMed: 18829560) »

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