Anti-NOXO1 抗体 (ab97788)
Key features and details
- Rabbit polyclonal to NOXO1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-NOXO1 antibody -
製品の詳細
Rabbit polyclonal to NOXO1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide, corresponding to a region within amino acids 307-370 of Human NOXO1 (NP_653204)
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ポジティブ･コントロール
- HCT116 whole cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab97788の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 41 kDa.
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| 特記事項 |
|---|
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WB
1/1000. Predicted molecular weight: 41 kDa. |
ターゲット情報
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機能
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. -
組織特異性
Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. -
配列類似性
Contains 1 PX (phox homology) domain.
Contains 2 SH3 domains. -
発生段階
Isoform 3 is expressed in fetal liver. -
ドメイン
The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region. -
細胞内局在
Cell membrane. Isoform 3 associates with the plasma membrane in a lipid-dependent manner. - Information by UniProt
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参照データベース
- Entrez Gene: 124056 Human
- Omim: 611256 Human
- SwissProt: Q8NFA2 Human
- Unigene: 191762 Human
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別名
- NADPH oxidase organizer 1 antibody
- NADPH oxidase regulatory protein antibody
- Nox organizer 1 antibody
see all
画像
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Western blot - Anti-NOXO1 antibody (ab97788)Anti-NOXO1 antibody (ab97788) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg
Predicted band size: 41 kDa
10% SDS PAGE
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab97788 は論文での使用が確認できていません。