Anti-NLRC5 抗体 (ab105411)
Key features and details
- Rabbit polyclonal to NLRC5
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-NLRC5 antibody -
製品の詳細
Rabbit polyclonal to NLRC5 -
由来種
Rabbit -
特異性
ab105411 is predicted to not cross react with other NLRP family members. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
An 18 amino acid peptide near the amino terminus of Human NLRC5 (NP_115582).
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ポジティブ･コントロール
- WB: EL4 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab105411の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 205 kDa.Can be blocked with NLRC5 peptide (ab196047).
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| 特記事項 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 205 kDa.Can be blocked with NLRC5 peptide (ab196047). |
ターゲット情報
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機能
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. -
組織特異性
Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. -
配列類似性
Belongs to the NLRP family.
Contains 26 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 434341 Mouse
- SwissProt: C3VPR6 Mouse
- Unigene: 334720 Mouse
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別名
- Caterpiller protein 16.1 antibody
- CLR16.1 antibody
- FLJ21709 antibody
see all
画像
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Western blot - Anti-NLRC5 antibody (ab105411)Anti-NLRC5 antibody (ab105411) at 1 µg/ml + EL4 cell lysate
Predicted band size: 205 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (13)
ab105411 は 13 報の論文で使用されています。
- Deng Y et al. The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis. Front Cell Dev Biol 9:669696 (2021). PubMed: 34095138
- Li P et al. Neuronal NLRC5 regulates MHC class I expression in Neuro-2a cells and also during hippocampal development. J Neurochem 152:182-194 (2020). PubMed: 31549732
- Wang B et al. NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway. Biochem Biophys Res Commun 528:545-553 (2020). PubMed: 32505342
- Fan Y et al. NLRC5 promotes cell migration and invasion by activating the PI3K/AKT signaling pathway in endometrial cancer. J Int Med Res 48:300060520925352 (2020). PubMed: 32431202
- He R et al. NLRC5 Inhibits Inflammation of Secretory Phase Ectopic Endometrial Stromal Cells by Up-Regulating Autophagy in Ovarian Endometriosis. Front Pharmacol 11:1281 (2020). PubMed: 33013364
