製品の概要
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製品名Nicastrin peptide
Nicastrin タンパク質・ペプチド 製品一覧
製品の詳細
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由来Synthetic
関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab4977 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Blocking
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製品の状態Liquid
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備考
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human nicastrin, catalog ab3444. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
関連情報
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別名
- Anterior pharynx defective 2
- APH 2
- APH2
see all -
機能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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組織特異性Widely expressed.
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配列類似性Belongs to the nicastrin family.
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細胞内局在Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
参考文献
ab4977 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"