Oligodendrocyte lineage in the mouse CNS

Oligodendrocytes (OLs) play a number of essential roles in the central nervous system (CNS) including providing metabolic support for neurons and myelination of axons.

Although they have previously been considered a homogenous cell population, single-cell RNA-sequencing has unveiled the transcriptional heterogeneity of oligodendrocytes, revealing twelve distinct subpopulations during mouse CNS development and adulthood. 

This poster, produced in association with Gonçalo Castelo-Branco, Sueli Marques and Elisa M. Floriddia from the Karolinska Institutet, highlights the transcriptional heterogeneity and distribution of oligodendrocyte populations in the CNS.

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