GABA 作動性ニューロン・マーカー

抑制性神経伝達物質の一つである γ アミノ酪酸(GABA)の受容体には、グルタミン酸受容体と同様イオンチャネル型と代謝型があります。イオンチャネル型 GABA 受容体はリガンド開口型イオンチャネルであり、塩化物イオン(Cl-)を流入させ、神経細胞膜の過分極を引き起こします。G タンパク質共役受容体(GPCR)である代謝型 GABA 受容体は、カリウムチャネルと結合しています。いずれの受容体も GABA が結合することにより、カリウムイオン(K+)を流出させ、神経細胞膜の過分極を引き起こします。

GABA 作動性ニューロンは、シナプスの結合と活動電位発火の頻度とタイミングを抑制的に調節します。この抑制機能の欠損は、てんかんなどの神経過興奮性疾患の一因となります。

GABA 作動性ニューロンの主なマーカー・タンパク質を紹介します。

GABA transporter 1 (GAT1)
A transporter on the cell membrane that moves GABA into the cell.

Mouse brain tissue sections stained with anti-GABA transporter 1 (ab64645).

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GAT1 inhibitors

NNC 711 (ab120364)​​Potent, selective GAT1 inhibitor
Potent, selective GAT-1 inhibitor
Tiagabine hydrochloride (ab120237)Selective GAT1 inhibitor

GABAB receptor 1 and 2
GABAB receptors are metabotropic transmembrane receptors for GABA that are linked via G-proteins to potassium channels. GABAB receptor 1 and GABAB receptor 2 assemble as heterodimers in neuronal membranes.

Rat brain (hippocampus) stained with anti-GABA B receptor 1 (red) (ab55051).

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GABAB receptor modulators

Saclofen (ab120327)Selective GABABreceptor agonist
(R)-Baclofen (ab120325)GABAB receptor agonist
CGP 35348 (ab120167)GABAB receptor agonist
CGP 7930 (ab120492)Positive GABABreceptor allosteric modulator
GS 39783 (ab120320)Novel GABAB positive allosteric modulator

The 65 kDa isomorph of glutamate decarboxylase that catalyzes the formation of GABA from glutamate.

Rat cerebellar cortex labeled with anti-GAD65 (ab26113).

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The 67 kDa isomorph of glutamate decarboxylase. Unlike GAD65, which is also expressed in the pancreas, GAD67 is CNS-specific.

Mouse cerebellum sections stained with anti-GAD67 (ab26116).

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