Anti-Natriuretic peptides A 抗体 [M622709] (ab2093)
Key features and details
- Mouse monoclonal [M622709] to Natriuretic peptides A
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Natriuretic peptides A antibody [M622709]
Natriuretic peptides A 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [M622709] to Natriuretic peptides A -
由来種
Mouse -
特異性
Affinity Constant: 2.2 x 1010 L/M -
種交差性
交差種: Human -
免疫原
Atrial Natriuretic Peptide whole molecule
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特記事項
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
M622709 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
ターゲット情報
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機能
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
関連疾患
Atrial standstill 2
Atrial fibrillation, familial, 6 -
配列類似性
Belongs to the natriuretic peptide family. -
翻訳後修飾
Cleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 4878 Human
- Omim: 108780 Human
- SwissProt: P01160 Human
- Unigene: 75640 Human
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別名
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
参考文献 (1)
ab2093 は 1 報の論文で使用されています。
- Therrien JP et al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt ; Human . PubMed: 20080656