Native Human IgG FC fragment protein (ab90285)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Native Human IgG FC fragment protein
Human IgG FC fragment タンパク質・ペプチド 製品一覧 -
生理活性
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests. -
精製度
> 95 % SDS-PAGE. -
発現系
Native -
タンパク質長
Full length protein -
Animal free
No -
由来
Native -
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予測される分子量
50 kDa -
配列の追加情報
Prepared from plasma
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab90285 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
備考
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm =1.46.
IgG is cleaved using Papain to product the Fc fragment. The IgG fc fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to cytotrophic reactions, binding of complement and catabolic rate control.
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Preservative: 0.05% Sodium azide
Constituents: 0.79% Tris HCl, 1.16% Sodium chloride
関連情報
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関連性
The Fc region is the constant region on an immunoglobulin molecule, the area that is exactly the same on all antibodies. The Fc region is found on the heavy chains and is not involved in binding antigens.
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プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab90285 は 12 報の論文で使用されています。
- Ma L et al. FOSL1 knockdown ameliorates DSS-induced inflammation and barrier damage in ulcerative colitis via MMP13 downregulation. Exp Ther Med 24:551 (2022). PubMed: 35978937
- Kamalakar A et al. JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. Bone 143:115657 (2021). PubMed: 32980561
- Qiu Y et al. Upregulation of AQP2 mediated by transcription factor FOXO1 inhibits TGF-ß-induced fibrosis in human urothelial cells. Exp Ther Med 22:1388 (2021). ChIP ; Human . PubMed: 34650636
- Vilhelmsson Timmermand O et al. A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen. Cancers (Basel) 13:N/A (2021). PubMed: 34298682
- Bill M et al. EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia. Clin Cancer Res 26:669-678 (2020). PubMed: 31672772