Anti-NAIP 抗体 (ab2549)

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Key features and details

  • Rabbit polyclonal to NAIP
  • Reacts with: Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-NAIP antibody
    NAIP 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to NAIP

  • 由来種

    Rabbit

  • 特異性

    This antibody detects recombinant human NAIP in extracts from Sf21 insect cells, but it is unknown as to whether this antibody detects the endogenous form.

  • 種交差性

    交差種: Human

  • 免疫原

    Synthetic peptide surrounding amino acid 506 of human NAIP.

  • 特記事項


    NAIP (Neuronal Apoptosis Inhibitor Protein) is a member of the IAPs (Inhibitor of Apoptosis Proteins) that function in cell death pathways to inhibit apoptosis. NAIP was discovered based on its association with a neurodegenerative disorder. Mutations and deletions in the NAIP gene locus is a contributing factor in spinal muscular atrophy. Coexpression of NAIP and hippocalcin protects neurons against calcium-induced cell death. NAIP is strongly expressed in anterior horn and motor cortex neurons of the normal brain. It is also found in human fetal neurons and in adult choroid plexus cells.

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製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • バッファー

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 1% BSA
  • Concentration information loading...

  • 精製度

    Immunogen affinity purified

  • 一次抗体 備考

    NAIP (Neuronal Apoptosis Inhibitor Protein) is a member of the IAPs (Inhibitor of Apoptosis Proteins) that function in cell death pathways to inhibit apoptosis. NAIP was discovered based on its association with a neurodegenerative disorder. Mutations and deletions in the NAIP gene locus is a contributing factor in spinal muscular atrophy. Coexpression of NAIP and hippocalcin protects neurons against calcium-induced cell death. NAIP is strongly expressed in anterior horn and motor cortex neurons of the normal brain. It is also found in human fetal neurons and in adult choroid plexus cells.

  • ポリ/モノ

    ポリクローナル

  • アイソタイプ

    IgG

  • 研究分野

ターゲット情報

  • 機能

    Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

  • 組織特異性

    Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.

  • 配列類似性

    Contains 3 BIR repeats.
    Contains 1 NACHT domain.
  • Information by UniProt

  • 参照データベース

    • 別名

      • Baculoviral IAP repeat containing 1 antibody
      • Baculoviral IAP repeat-containing protein 1 antibody
      • BIRC 1 antibody
      • BIRC1 antibody
      • BIRC1_HUMAN antibody
      • Birc1a antibody
      • FLJ42520 antibody
      • NAIP antibody
      • Naip1 antibody
      • Neuronal apoptosis inhibitory protein antibody
      • NLR family apoptosis inhibitory protein antibody
      • NLR family BIR domain containing 1 antibody
      • NLRB 1 antibody
      • NLRB1 antibody
      • Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody
      • Psi neuronal apoptosis inhibitory protein antibody
      • psiNAIP antibody
      • Similar to occludin antibody
      see all

    参考文献 (1)

    ab2549 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab2549 は 1 報の論文で使用されています。

    • Romanish MT  et al. A novel protein isoform of the multicopy human NAIP gene derives from intragenic Alu SINE promoters. PLoS One 4:e5761 (2009). WB ; Human . PubMed: 19488400

    レビューと Q&A

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    レビューを送る 質問を送る

    Question

    Customer would like to know the sequence of the immunogen.

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    Answer

    a.a. 473-490 of human NAIP.

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