製品の概要

  • 製品名

    Naftopidil hydrochloride, alpha1 Adrenoceptor antagonist
  • 製品の詳細

    α1 Adrenoceptor antagonist
  • 生理活性の詳細

    α1 Adrenoceptor antagonist. pKi values are 3.7, 20 and 1.2 for α1a, α1b and α1d, respectively. Orally active. Implicated in benign prostate hyperplasia and bladder obstruction. Antihypertensive.
  • 精製度

    > 98%
  • CAS 番号

    57149-07-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Kanda H  et al. Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer 122:444-51 (2008). Read more (PubMed: 17918159) »
  • Takei R  et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol 79:447-54 (1999). Read more (PubMed: 10361884) »
  • Yamada S  et al. Binding characteristics of naftopidil and alpha 1-adrenoceptor antagonists to prostatic alpha-adrenoceptors in benign prostatic hypertrophy. Life Sci 50:127-35 (1992). Read more (PubMed: 1370569) »

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