PE Anti-Myeloperoxidase 抗体 [2C7] (ab11730)
Key features and details
- PE Mouse monoclonal [2C7] to Myeloperoxidase
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
PE Anti-Myeloperoxidase antibody [2C7]
Myeloperoxidase 一次抗体 製品一覧 -
製品の詳細
PE Mouse monoclonal [2C7] to Myeloperoxidase -
由来種
Mouse -
標識
PE. Ex: 488nm, Em: 575nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human Myeloperoxidase.
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特記事項
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA, 5% Sucrose -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
Purified IgG prepared by affinity chromatography. -
ポリ/モノ
モノクローナル -
クローン名
2C7 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Assay kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11730の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
Use 10µl for 106 cells.
ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10 µl of undiluted antibody to label 106 cells in 100 µl. This antibody may be used for the flow cytometric detection of myeloid cells following membrane permeablisation. |
特記事項 |
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Flow Cyt
Use 10µl for 106 cells. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10 µl of undiluted antibody to label 106 cells in 100 µl. This antibody may be used for the flow cytometric detection of myeloid cells following membrane permeablisation. |
ターゲット情報
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機能
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. -
関連疾患
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. -
配列類似性
Belongs to the peroxidase family. XPO subfamily. -
細胞内局在
Lysosome. - Information by UniProt
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参照データベース
- Entrez Gene: 4353 Human
- Omim: 606989 Human
- SwissProt: P05164 Human
- Unigene: 458272 Human
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別名
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 1.11.1.7 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab11730 は 3 報の論文で使用されています。
- Zhang L et al. Development of Neuroregenerative Gene Therapy to Reverse Glial Scar Tissue Back to Neuron-Enriched Tissue. Front Cell Neurosci 14:594170 (2020). PubMed: 33250718
- Sondo E et al. High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation. Front Immunol 10:963 (2019). PubMed: 31114589
- Patschan S et al. Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis. Int J Nephrol 2012:715049 (2012). PubMed: 22792461