Key features and details
- Mouse monoclonal [996/1] to MUC2
- Reacts with: Human
- Isotype: IgG1
製品名Anti-MUC2 antibody [996/1]
MUC2 一次抗体 製品一覧
製品の詳細Mouse monoclonal [996/1] to MUC2
特異性ab11197 recognises the human MUC2 mucin, and shows no cross-reactivity with MUC1, MUC3 or MUC4 mucins. In tissue sections ab11197 recognises colon, liver and prostate tissues strongly. The antibody recognises malignant colonic mucosa as well as normal mucosa.
Synthetic peptide corresponding to Human MUC2. Synthetic peptide: TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT T This is from the tandem repeat are of the sequence and can be found starting at amino acids 1933 and 2163
TPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTT
Database link: Q02817
- Normal colon
We have removed mouse from our list of reactive species based on contradictory results from researchers. We have had increased reports of negative staining results in IHC-P with mouse tissue. We do not batch test this antibody with mouse and we will no longer guarantee it for mouse reactivity.
Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.09% Sodium azide
Concentration information loading...
精製度Protein G purified
特記事項（精製）Purified IgG prepared by affinity chromatography from tissue culture supernatant.
機能Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
組織特異性Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
配列類似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 2 VWFC domains.
Contains 4 VWFD domains.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
細胞内局在Secreted. In the intestine, secreted into the inner and outer mucus layers.
- Information by UniProt
- Intestinal mucin 2 antibody
- Intestinal mucin-2 antibody
- MLP antibody
ab11197 は 32 報の論文で使用されています。
- Alfi O et al. Human Nasal Turbinate Tissues in Organ Culture as a Model for Human Cytomegalovirus Infection at the Mucosal Entry Site. J Virol 94:N/A (2020). PubMed: 32727881
- Fallah S & Beaulieu JF The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation. Cells 9:N/A (2020). PubMed: 32823612
- Tran TQ et al. a-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. Nat Cancer 1:345-358 (2020). PubMed: 32832918
- Rajan A et al. Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog 16:e1008851 (2020). PubMed: 32986782
- Wang Y et al. Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. J Exp Med 217:N/A (2020). PubMed: 31753849