MTEP hydrochloride, mGlu5 antagonist (ab120035)
Key features and details
- Potent, selective mGlu5 antagonist
- CAS Number: 1186195-60-7
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
MTEP hydrochloride, mGlu5 antagonist -
製品の詳細
Potent, selective mGlu5 antagonist -
生理活性の詳細
Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
1186195-60-7 -
構造式
製品の特性
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体系名
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride -
分子量
236.72 -
分子式
C11H8N2S.HCl -
PubChem 登録番号
45073467 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cc2nc(C#Cc1cccnc1)cs2.Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (25)
ab120035 は 25 報の論文で使用されています。
- Hu Z et al. Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease. Transl Psychiatry 12:96 (2022). PubMed: 35260557
- Hu C et al. Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents. Front Cell Dev Biol 10:844378 (2022). PubMed: 35646890
- Zhang Y et al. Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats. J Alzheimers Dis 89:335-350 (2022). PubMed: 35871344
- Cannady R et al. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369 (2017). PubMed: 28320841
- Travaglia A et al. Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33 (2016). PubMed: 27428652