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mSin3A peptide (ab4995)

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Key features and details

  • Suitable for: Blocking

製品の詳細

  • 製品名

    mSin3A peptide

  • Animal free

    No

  • 由来

    Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab4995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態

    Liquid

  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the mouse mSin3A, catalog ab3479. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名

    • AW553200
    • DKFZP434K2235
    • FLJ90319
    • Histone deacetylase complex subunit Sin 3a
    • Histone deacetylase complex subunit Sin3a
    • KIAA0700
    • Kiaa4126
    • mKIAA4126
    • Paired amphipathic helix protein Sin 3a
    • Paired amphipathic helix protein Sin3a
    • Sin 3a
    • SIN3 homolog A
    • SIN3 homolog A transcription regulator
    • SIN3 homolog A transcription regulator (yeast)
    • SIN3 transcription regulator homolog A
    • Sin3a
    • SIN3A protein
    • SIN3A_HUMAN
    • Transcriptional co repressor Sin 3A
    • Transcriptional co repressor Sin3A
    • Transcriptional corepressor Sin3a
    • Transcriptional regulator SIN3A
    see all

  • 機能

    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.

  • 配列類似性

    Contains 3 PAH (paired amphipathic helix) domains.

  • 翻訳後修飾

    SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.

  • 細胞内局在

    Nucleus. Nucleus > nucleolus. Recruited to the nucleolus by SAP30L.
  • Information by UniProt

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献 (1)

ab4995 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab4995 は 1 報の論文で使用されています。

  • Kudva AK  et al. Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture. Acta Biomater 90:287-299 (2019). PubMed: 30905864

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