Anti-MRP8 + MRP14 抗体 [5.5] (ab20222)
Key features and details
- Mouse monoclonal [5.5] to MRP8 + MRP14
- Suitable for: IHC-Fr, IP, WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-MRP8 + MRP14 antibody [5.5]
MRP8 + MRP14 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [5.5] to MRP8 + MRP14 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Fr, IP, WBmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human MRP8 + MRP14. acute monocytic leukaemia cells (Human).
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ポジティブ･コントロール
- Neutrophil lysate (particularly neutrophils from spleen)
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
5.5 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab20222の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
Predicted molecular weight MRP8 10.8 kDa, MRP14 13 kDa. |
| 特記事項 |
|---|
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IHC-Fr
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight MRP8 10.8 kDa, MRP14 13 kDa. |
ターゲット情報
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関連性
MRP8 and MRP14 are members of the S100 family of proteins containing 2 EF hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. -
細胞内局在
Cytoplasmic and Nuclear -
参照データベース
- Entrez Gene: 6279 Human
- Entrez Gene: 6280 Human
- Omim: 123885 Human
- Omim: 123886 Human
- SwissProt: P05109 Human
- SwissProt: P06702 Human
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別名
- CAGA antibody
- CAGB antibody
- Calgranulin A antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab20222 は 4 報の論文で使用されています。
- Wen H et al. Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma. Nat Med 24:154-164 (2018). WB . PubMed: 29291352
- Wang Y et al. Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. J Clin Invest 124:2160-71 (2014). WB, IHC ; Mouse . PubMed: 24691441
- Hessian PA & Fisher L The heterodimeric complex of MRP-8 (S100A8) and MRP-14 (S100A9). Antibody recognition, epitope definition and the implications for structure. Eur J Biochem 268:353-63 (2001). PubMed: 11168370
- Hogg N et al. Monoclonal antibody 5.5 reacts with p8,14, a myeloid molecule associated with some vascular endothelium. Eur J Immunol 19:1053-61 (1989). PubMed: 2666142