Monastrol, cell permeable mitosis inhibitor (ab141087)
Key features and details
- Potent and cell permeable mitosis inhibitor. Kinesin Eg5 inhibitor.
- CAS Number: 329689-23-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Monastrol, cell permeable mitosis inhibitor -
製品の詳細
Potent and cell permeable mitosis inhibitor. Kinesin Eg5 inhibitor. -
精製度
> 99% -
CAS 番号
329689-23-8 -
構造式
製品の特性
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体系名
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester -
分子量
292.35 -
分子式
C14H16N2O3S -
PubChem 登録番号
2987927 -
保存方法
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C(OCC)C2=C(C)NC(=S)NC2c1cc(O)ccc1 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab141087 は 3 報の論文で使用されています。
- Kohle F et al. Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis. J Neuroinflammation 20:139 (2023). PubMed: 37296476
- Walton CC et al. Primary neurons can enter M-phase. Sci Rep 9:4594 (2019). PubMed: 30872646
- Cho YC et al. Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1. Cell Death Differ 22:1605-17 (2015). PubMed: 25633196