Anti-MMP13 抗体 [M33] (ab1010)
製品の概要
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製品名Anti-MMP13 antibody [M33]
MMP13 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [M33] to MMP13
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由来種Mouse
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特異性Based on Western blotting, the antibody reacts with human procollagenase-3. The antibody does not cross react with MT1-MMP latent form (MMP-14), MT2-MMP catalytic domain (MMP-15), MT3-MMP catalytic domain (MMP-16), MT4-MMP catalytic domain (MMP-17), MT5-MMP catalytic domain (MMP-18), Gelatinase A (MMP-2) latent form, Gelatinase B (MMP-9) latent form or Collagenase 2 (MMP-8) latent form.
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アプリケーション適用あり: WB, ELISAmore details
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種交差性交差種: Human
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免疫原
Recombinant human procollagenase-3 expressed in insect cells
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特記事項MMP is Matrix Metalloproteinase.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーPreservative: 0.01% Sodium azide
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Concentration information loading... -
精製度Protein G purified
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ポリ/モノモノクローナル
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クローン名M33
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アイソタイプIgG1
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軽鎖の種類unknown
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab1010 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/2000. Detects a band of approximately 50 kDa (predicted molecular weight: 53 kDa). | |
| ELISA | 1/2000. |
ターゲット情報
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機能Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
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組織特異性Seems to be specific to breast carcinomas.
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関連疾患Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age.
Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. -
配列類似性Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains. -
ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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細胞内局在Secreted > extracellular space > extracellular matrix.
- Information by UniProt
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参照データベース
- Entrez Gene: 4322 Human
- Omim: 600108 Human
- SwissProt: P45452 Human
- Unigene: 2936 Human
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別名
- CLG 3 antibody
- CLG3 antibody
- Collagenase 3 antibody
see all
データシートおよび資料
プロトコール
参考文献
ab1010 has not yet been referenced specifically in any publications.
