Key features and details
- Rabbit polyclonal to MMP12
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
バッファーPreservative: 0.02% Thimerosal (merthiolate)
Constituents: 69% PBS, 30% Glycerol
Concentration information loading...
精製度Protein A purified
Our Abpromise guarantee covers the use of ab128030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 54 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
機能May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
組織特異性Found in alveolar macrophages but not in peripheral blood monocytes.
配列類似性Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
細胞内局在Secreted > extracellular space > extracellular matrix.
- Information by UniProt
製品の状態The presence of a 22kDa truncated active form of MMP-12 in vitro as well as in vivo due to the internal autolytic cleavage of the C-terminus.
- EC 126.96.36.199 antibody
- HME antibody
- Macrophage elastase antibody
ab128030 は 1 報の論文で使用されています。
- Reed HO et al. Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. J Clin Invest 129:2514-2526 (2019). PubMed: 30946031