MLi-2, LRRK2 inhibitor (ab254528)
Key features and details
- Potent and selective LRRK2 inhibitor
- CAS Number: 1627091-47-7
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
MLi-2, LRRK2 inhibitor -
製品の詳細
Potent and selective LRRK2 inhibitor -
生理活性の詳細
Potent and selective LRRK2 inhibitor. Inhibits LRRK2 in cell-free (IC50 = 0.76 nM), cell-based (IC50 = 1.4 nM) and radioligand-binding (IC50 = 3.4 nM) assays. Greater than 295-fold selective against a panel of receptors, channels and over 300 kinases. Oral dosing results in reduced Ser935 phosphorylation of LRRK2 in animal models.
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精製度
> 98% -
CAS 番号
1627091-47-7 -
構造式
製品の特性
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体系名
(2R,6S)-2,6-Dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine
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分子量
379.46 -
分子式
C21H25N5O2 -
PubChem 登録番号
78319901 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C -
由来
Synthetic
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研究分野
関連製品
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Alternative Versions
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab254528 は 2 報の論文で使用されています。
- Fdez E et al. Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy. STAR Protoc 4:102024 (2023). PubMed: 36856766
- Fdez E et al. Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement. iScience 25:104476 (2022). PubMed: 35721463