Key features and details
- Mouse monoclonal [B-D54] to MICB
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
保存方法Shipped at 4°C. Store at 4°C (stable for up to 12 months). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Sterile-filtered through 0.22 µm. Carrier and preservative free
Concentration information loading...
精製度Protein A purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab270760 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Use 1µl for 106 cells.
Use 1µl for 106 cells.
機能Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
組織特異性Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
関連疾患Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=The MICB*004 allele is associated with rheumatoid arthritis.
Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
配列類似性Belongs to the MHC class I family. MIC subfamily.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
翻訳後修飾Proteolytically cleaved and released from the cell surface of tumor cells.
細胞内局在Cell membrane. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
- Information by UniProt
- MHC class I chain related protein B antibody
- MHC class I chain related protein B2 antibody
- MHC class I like molecule PERB11.2 IMX antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.