Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist (ab120072)
Key features and details
- α7 Nicotinic receptor antagonist
- CAS Number: 112825-05-5
- Purity: > 97%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Delphinium
製品の概要
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製品名
Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist -
製品の詳細
α7 Nicotinic receptor antagonist -
別名
- MLA
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生理活性の詳細
Potent, selective antagonist at α7-containing nicotinic receptors.
Also available in simple stock solutions (ab146684) - add 1 ml of water to get an exact, ready-to-use concentration. -
精製度
> 97% -
CAS 番号
112825-05-5 -
構造式
製品の特性
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体系名
[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
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分子量
874.92 -
分子式
C37H50N2O10.C6H8O7 -
PubChem 登録番号
90479749 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]1[C@@]([C@H](C23)OC)([C@]5(C[C@@H]([C@H]6C[C@@H]4[C@@H]5[C@H]6OC)OC)O)O)OC)COC(=O)C7=CC=CC=C7N8C(=O)C[C@@H](C8=O)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O -
由来
Delphinium
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (7)
ab120072 は 7 報の論文で使用されています。
- Chang KW et al. PNU282987 alleviates Aß-induced anxiety and depressive-like behaviors through upregulation of a7nAChR by ERK-serotonin receptors pathway. Neurosci Lett 731:135118 (2020). PubMed: 32502508
- Nikiforuk A et al. The combination of memantine and galantamine improves cognition in rats: The synergistic role of the a7 nicotinic acetylcholine and NMDA receptors. Behav Brain Res 313:214-8 (2016). PubMed: 27435422
- Zhang Y et al. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via a7 receptor in hippocampus. Cell Res 26:728-42 (2016). PubMed: 27103432
- Sadigh-Eteghad S et al. Effect of alpha-7 nicotinic acetylcholine receptor activation on beta-amyloid induced recognition memory impairment. Possible role of neurovascular function. Acta Cir Bras 30:736-42 (2015). PubMed: 26647792
- Baxter JC et al. Functional expression of a7-nicotinic acetylcholine receptors by muscle afferent neurons. J Neurophysiol 112:1549-58 (2014). PubMed: 24966300
- Uteshev VV Somatic integration of single ion channel responses of a7 nicotinic acetylcholine receptors enhanced by PNU-120596. PLoS One 7:e32951 (2012). PubMed: 22479351
- Bell KA et al. Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain a4 and ß2 subunits. Neuropharmacology 61:1379-88 (2011). PubMed: 21878344