製品の概要

  • 製品名

    Metergoline, 5-HT receptor antagonist
  • 製品の詳細

    Potent 5-HT receptor antagonist
  • 生理活性の詳細

    Potent 5-HT1, 5-HT2 and 5-HT7 receptor antagonist (Ki = 16 nM at h5-HT7 receptor). Additionally displays activity at dopamine receptors. Elicits cell death.
  • 精製度

    > 99%
  • CAS 番号

    17692-51-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Kang K  et al. Metergoline-induced cell death in Candida krusei. Fungal Biol 115:302-9 (2011). Read more (PubMed: 21354537) »
  • Hooker JM  et al. Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates. Bioorg Med Chem 18:7739-45 (2010). Read more (PubMed: 20451398) »
  • Knight JA  et al. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol Pharmacol 75:374-80 (2009). Read more (PubMed: 18996971) »

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