製品の概要

  • 製品名

    Mepyramine maleate, H1 inverse agonist
  • 製品の詳細

    Selective H1 inverse agonist
  • 別名

    • Pyrilamine maleate
  • 生理活性の詳細

    Selective H1 receptor inverse agonist (Ki = 0.4 nM). Blood-brain barrier permeable. Shows antihistaminergic action. Additionally, inhibits histamine-induced inositol phosphate production and intracellular calcium mobilization.
  • 精製度

    > 99%
  • CAS 番号

    59-33-6
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Parsons ME & Ganellin CR Histamine and its receptors. Br J Pharmacol 147 Suppl 1:S127-35 (2006). Read more (PubMed: 16402096) »
  • Fitzsimons CP  et al. Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein. J Biol Chem 279:34431-9 (2004). Read more (PubMed: 15192105) »
  • Yamazaki M  et al. Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique. Biol Pharm Bull 17:676-9 (1994). Read more (PubMed: 7920432) »
See 1 Publication for this product

レビューと Q&A

Answer

The SDS sheet is available for download above the "CoA" button on our website datasheet. Please be advised that our products are for research use only and are not for diagnostic or therapeutic use and are not for use in humans.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

登録