Memantine hydrochloride, NMDA antagonist (ab120249)
Key features and details
- NMDA antagonist, ion channel site
- CAS Number: 41100-52-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Memantine hydrochloride, NMDA antagonist -
製品の詳細
NMDA antagonist, ion channel site -
生理活性の詳細
Antagonist at the NMDA receptor. Acts as a fast, voltage-dependent, open channel NMDA receptor blocker. Used in the clinic to treat Alzheimer's disease. Cognitive enhancer and anxiolytic in vivo.
Also available in simple stock solutions (ab146687) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
41100-52-1 -
構造式
製品の特性
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体系名
3,5-Dimethyl-1-adamantanamine hydrochloride -
分子量
215.77 -
分子式
C12H21N.HCl -
PubChem 登録番号
181458 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.CC13CC2(C)CC(N)(C1)CC(C2)C3 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120249, Memantine hydrochloride, NMDA antagonist
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Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of memantine (5 or 30 μM; ab120249) in naive adult male C57BL/6J mice.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120249 は 1 報の論文で使用されています。
- Wills TA et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A 109:E278-87 (2012). PubMed: 22219357