Anti-Matriptase 2 抗体 - Cytoplasmic domain (ab56180)
Key features and details
- Rabbit polyclonal to Matriptase 2 - Cytoplasmic domain
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Matriptase 2 antibody - Cytoplasmic domain
Matriptase 2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Matriptase 2 - Cytoplasmic domain -
由来種
Rabbit -
特異性
ab56180 reacts with Matripase 2 (TMPRSS6) and does not react with the other TMPRSSs. ab56180 recognizes all of the listed forms of Matripase 2. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide based on the aminoterminal end (cytoplasmic domain) of Matripase 2 (Human).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 2.9% Sodium chloride, PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab56180の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
1/1000 - 1/5000. Predicted molecular weight: 89 kDa.
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特記事項 |
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WB
1/1000 - 1/5000. Predicted molecular weight: 89 kDa. |
ターゲット情報
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機能
Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter. -
組織特異性
Liver specific. -
関連疾患
Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]; also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. -
配列類似性
Belongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 3 LDL-receptor class A domains.
Contains 1 peptidase S1 domain. -
ドメイン
Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s). -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 164656 Human
- Omim: 609862 Human
- SwissProt: Q8IU80 Human
- Unigene: 370885 Human
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別名
- IRIDA antibody
- Matriptase-2 antibody
- Membrane bound mosaic serine proteinase matriptase 2 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab56180 は 6 報の論文で使用されています。
- Rosato BE et al. SEC23B Loss-of-Function Suppresses Hepcidin Expression by Impairing Glycosylation Pathway in Human Hepatic Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35163229
- Dimitriadis A et al. The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway. FEBS Open Bio 11:237-250 (2021). PubMed: 33247551
- Foka P et al. HCV-Induced Immunometabolic Crosstalk in a Triple-Cell Co-Culture Model Capable of Simulating Systemic Iron Homeostasis. Cells 10:N/A (2021). PubMed: 34571900
- Lamothe SM et al. The Human Ether-a-go-go-related Gene (hERG) Potassium Channel Represents an Unusual Target for Protease-mediated Damage. J Biol Chem 291:20387-401 (2016). PubMed: 27502273
- Foka P et al. A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression. Cell Mol Life Sci N/A:N/A (2014). WB . PubMed: 24718935
- Lakhal S et al. Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS. J Biol Chem 286:4090-7 (2011). WB ; Human . PubMed: 20966077