Anti-Mannan Binding Lectin/MBL 抗体 [1E2] (ab23458)
Key features and details
- Mouse monoclonal [1E2] to Mannan Binding Lectin/MBL
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Mannan Binding Lectin/MBL antibody [1E2]
Mannan Binding Lectin/MBL 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [1E2] to Mannan Binding Lectin/MBL -
由来種
Mouse -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human Mannan Binding Lectin/MBL.
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特記事項
ab23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading... -
精製度
Protein G purified -
一次抗体 備考
Ab 23458 reacts with human MBL both in its poltmeric conforation and as a single subunit of moleculat mass 26 kDa. Can be applied for quantitative measurement of MBL in plasma or serum. -
ポリ/モノ
モノクローナル -
クローン名
1E2 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab23458の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
1/10000.
|
|
| WB |
Use at an assay dependent dilution. Predicted molecular weight: 26 kDa.
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| 特記事項 |
|---|
|
ELISA
1/10000. |
|
WB
Use at an assay dependent dilution. Predicted molecular weight: 26 kDa. |
ターゲット情報
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機能
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. -
組織特異性
Plasma protein produced mainly in the liver. -
関連疾患
Note=There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections. -
配列類似性
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 4153 Human
- Omim: 154545 Human
- SwissProt: P11226 Human
- Unigene: 499674 Human
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別名
- COLEC 1 antibody
- COLEC1 antibody
- Collectin-1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab23458 は 3 報の論文で使用されています。
- Harboe M et al. Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions. Clin Exp Immunol 144:512-20 (2006). PubMed: 16734621
- Downing I et al. Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin. Immunology 109:360-4 (2003). PubMed: 12807481
- Sund S et al. Complement activation in early protocol kidney graft biopsies after living-donor transplantation. Transplantation 75:1204-13 (2003). PubMed: 12717204