Anti-MAML2 抗体 [MAML2/1302] - BSA and Azide free (ab269753)
Key features and details
- Mouse monoclonal [MAML2/1302] to MAML2 - BSA and Azide free
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-MAML2 antibody [MAML2/1302] - BSA and Azide free
MAML2 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MAML2/1302] to MAML2 - BSA and Azide free -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human MAML2 aa 1-1156.
Database link: Q8IZL2 -
ポジティブ・コントロール
- Human pancreas, Human colon carcinoma, Human bladder carcinoma and Human placenta tissues.
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特記事項
ab269753 is a carrier free version of ab218338.
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.
This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Constituent: PBS -
キャリア・フリー
はい -
Concentration information loading...
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精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
MAML2/1302 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab269753の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. -
組織特異性
Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. -
関連疾患
Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas. -
配列類似性
Belongs to the mastermind family. -
ドメイン
The C-terminal domain is required for transcriptional activation. -
細胞内局在
Nucleus speckle. Nuclear, in a punctate manner. - Information by UniProt
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参照データベース
- Entrez Gene: 84441 Human
- Omim: 607537 Human
- SwissProt: Q8IZL2 Human
- Unigene: 428214 Human
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別名
- KIAA1819 antibody
- Mam 2 antibody
- Mam-2 antibody
see all
画像
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Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human pancreas tissue labeling MAML2 with ab218338 at 1 μg/ml dilution, followed by conjugation to the secondary antibody.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab218338). -
Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human colon carcinoma tissue labeling MAML2 with ab218338 at 1 μg/ml dilution, followed by conjugation to the secondary antibody.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab218338). -
Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human bladder carcinoma tissue labeling MAML2 with ab218338 at 1 μg/ml dilution, followed by conjugation to the secondary antibody.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab218338). -
Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human placenta tissue labeling MAML2 with ab218338 at 1 μg/ml dilution, followed by conjugation to the secondary antibody.
This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab218338).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab269753 は論文での使用が確認できていません。