Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR604] to MALT1/MLT - BSA and Azide free
- Suitable for: ICC, WB
- Reacts with: Human
製品名Anti-MALT1/MLT antibody [EPR604] - BSA and Azide free
MALT1/MLT 一次抗体 製品一覧
製品の詳細Rabbit monoclonal [EPR604] to MALT1/MLT - BSA and Azide free
アプリケーション適用あり: ICC, WBmore details
適用なし: Flow Cyt,IHC-P or IP
Synthetic peptide within Human MALT1/MLT aa 800-900. The exact sequence is proprietary.
ab247917 is the carrier-free version of ab109724 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.
Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Ab247917 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.
Maxpar® is a trademark of Fluidigm Canada Inc.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. This product was previously labelled as MALT1
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
保存方法Shipped at 4°C. Store at +4°C. Do Not Freeze.
Concentration information loading...
Our Abpromise guarantee covers the use of ab247917 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC||Use at an assay dependent concentration.|
|WB||Use at an assay dependent concentration. Predicted molecular weight: 92 kDa.|
機能Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
組織特異性Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
関連疾患Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
配列類似性Belongs to the peptidase C14B family.
Contains 1 death domain.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
細胞内局在Cytoplasm > perinuclear region. Nucleus. Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
- Information by UniProt
- Caspase like protein antibody
- DKFZp434L132 antibody
- IMD12 antibody
All lanes : Anti-MALT1/MLT antibody [EPR604] (ab109724) at 1/1000 dilution
Lane 1 : Jurkat lysate
Lane 2 : K562 lysate
Lane 3 : Bone marrow lysate
Lane 4 : PBMC lysates
Lysates/proteins at 10 µg per lane.
All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 92 kDa
This data was developed using ab109724, the same antibody clone in a different buffer formulation.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.