LY2886721, BACE-1 inhibitor (ab223886)
Key features and details
- Potent and selective BACE-1 inhibitor
- CAS Number: 1262036-50-9
- Purity: > 98%
Soluble in DMSO to 20 mM, in Ethanol < 2 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY2886721, BACE-1 inhibitor -
製品の詳細
Potent and selective BACE-1 inhibitor -
別名
- LY2886721
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生理活性の詳細
Potent and selective BACE-1 inhibitor (IC50 = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC50 of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC50 values are 18.5 nM and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC50 ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.
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精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 2299 LY2886721. 2299-25 is the same size as the 25 mg size of ab223886.
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CAS 番号
1262036-50-9 -
構造式
製品の特性
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体系名
N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
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分子量
390.41 -
分子式
C18H16F2N4O2S -
PubChem 登録番号
49837968 -
保存方法
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 20 mM, in Ethanol < 2 mM
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SMILES 線形表記
C1[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab223886 は論文での使用が確認できていません。