LY 364947, ATP-competitive TGFbeta receptor kinase I inhibitor (ab141890)
Key features and details
- Potent, selective ATP-competitive TGFβ receptor kinase I inhibitor
- CAS Number: 396129-53-6
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 364947, ATP-competitive TGFbeta receptor kinase I inhibitor -
製品の詳細
Potent, selective ATP-competitive TGFβ receptor kinase I inhibitor -
別名
- HTS 466284
- TGF-beta inhibitor
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精製度
> 98% -
CAS 番号
396129-53-6 -
構造式
製品の特性
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体系名
4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline -
分子量
272.30 -
分子式
C17H12N4 -
PubChem 登録番号
447966 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (8)
ab141890 は 8 報の論文で使用されています。
- Gilham D et al. Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment. Biomedicines 11:N/A (2023). PubMed: 37371758
- Zhang X et al. Carbon nanotubes promote alveolar macrophages toward M2 polarization mediated epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation. Nanotoxicology 15:588-604 (2021). PubMed: 33840345
- Huang C et al. Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-ß signalling. J Cell Commun Signal 14:53-66 (2020). PubMed: 31399854
- Wang XL & Huang C Difference of TGF-ß/Smads signaling pathway in epithelial-mesenchymal transition of normal colonic epithelial cells induced by tumor-associated fibroblasts and colon cancer cells. Mol Biol Rep N/A:N/A (2019). PubMed: 30835040
- Shan L et al. Epigallocatechin gallate improves airway inflammation through TGF-ß1 signaling pathway in asthmatic mice. Mol Med Rep 18:2088-2096 (2018). PubMed: 29916550
- Chen K et al. Epigallocatechingallate attenuates myocardial injury in a mouse model of heart failure through TGF-ß1/Smad3 signaling pathway. Mol Med Rep 17:7652-7660 (2018). PubMed: 29620209
- Huang C et al. Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-ß pathway. J Cell Physiol N/A:N/A (2018). Human . PubMed: 30536375
- Yang W et al. A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells. Invest New Drugs N/A:N/A (2018). PubMed: 30488243